منابع مشابه
URINARY 6b-HYDROXYCORTISOL EXCRETION IN RHEUMATOID ARTHRITIS
The objective was to analyse whether the activity of the cytochrome P450 isoenzyme CYP3A4 is altered by disease activity of rheumatoid arthritis (RA). Urinary 6b-hydroxycortisol excretion, expressed as a fraction of the urinary creatinine output, was measured in 21 patients with RA treated with three different disease-modifying anti-rheumatic drugs (DMARDs) over 24 weeks. There were no correlat...
متن کامل4,4,6a,6b,11,12,14b-Heptamethyl-16-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octadecahydro-12b,8a-(epoxymethano)picen-3-yl acetate
The title compound, C32H48O4, which was extracted from the bark of Rhododendron arboreum, consists of five fused rings to which an acetate and seven methyl groups are attached. The A, D and E rings adopt chair conformations, the B ring is in a distorted chair and the C ring is in a half-chair conformation. The five-membered ring formed by the lactone group, which bridges from the A/B to the B/C...
متن کامل5b,6b-Epoxy-17-oxoandrostan-3b-yl acetate and 5b,6b-epoxy-20-oxo- pregnan-3b-yl acetate
In the title compounds, C21H30O4, (I), and C23H34O4, (II), respectively, which are valuable intermediates in the synthesis of important steroid derivatives, rings A and B are cis(5 ,10 )-fused. The two molecules have similar conformations of rings A, B and C. The presence of the 5 ,6 -epoxide group induces a significant twist of the steroid nucleus and a strong flattening of the B ring. The dif...
متن کاملAssociation of Human Herpesvirus-6B with Mesial Temporal Lobe Epilepsy
BACKGROUND Human herpesvirus-6 (HHV-6) is a beta-herpesvirus with 90% seroprevalence that infects and establishes latency in the central nervous system. Two HHV-6 variants are known: HHV-6A and HHV-6B. Active infection or reactivation of HHV-6 in the brain is associated with neurological disorders, including epilepsy, encephalitis, and multiple sclerosis. In a preliminary study, we found HHV-6B...
متن کاملInhibition of herpesvirus-6B RNA replication by short interference RNAs.
RNA interference (RNAi) is a process of sequence-specific gene silencing, which is initiated by double-stranded RNA (dsRNA). RNAi may also serve as an antiviral system in vertebrates. This study describes the inhibition of herpesvirus-6B (HHV-6B) replication by short interference RNAs (siRNAs) that are targeted to the U38 sequence that encodes DNA polymerase. When virus-infected SupT1 cells wer...
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ژورنال
عنوان ژورنال: Philologus
سال: 1863
ISSN: 2196-7008,0031-7985
DOI: 10.1524/phil.1863.19.14.465